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Nelson Angstrom works as a mental health counselor in an Adult Day Treatment Center. On Christmas morning he learns that one of his clients, Michael DiLorenzo, has committed suicide in a desperate attempt to flee the voices in his head. Nelson is the son of Rabbit Angstrom, the central character in a series of John Updike novels that began with Rabbit Run (1960) and ended with Rabbit’s death in Rabbit at Rest (1990).