50/50 is a delicate balancing act: a comedy-drama about a 27-year-old man named Adam (the amazing Joseph Gordon-Levitt) who learns he has a malignant spinal tumor and a 50 percent chance of surviving it. The lovely surprise is that writer Will Reiser and  director Jonathan Levine pull off twin feats: they sustain a tone pitched midway between ironic and poignant, and they touch the audience without pushing pathos at us.

The movie aims to steer clear of the first-you-laugh-and-then-you-cry agenda of Terms of Endearment, in which Debra Winger plays the young woman whose cancer foregrounds her dysfunctional relationship with her difficult mother (Shirley MacLaine). The idea is instead to present the cancer and chemotherapy as "Adam's Adventures in Wonderland." Everything he experiences is brand new and bizarre, and he has to figure out how to thread his way through this obstacle course of the unexpected.